PICC lines are most frequently placed in the superficial veins proximal to the antecubital fossa (usually in the basilic or the cephalic veins). However, they may also be placed translumbar or transhepatically when the SVC is thrombosed or occluded.

An interventional radiologist will perform the insertion of a PICC line. To confirm correct placement in the SVC and rule out a pneumothorax, a chest X-ray is taken. It is important that post insertion, all patients be monitored for signs and symptoms of local and systemic infection. Additionally, the site should be continually inspected for bleeding, drainage, hematoma, or seroma.

PICC line (red) inserted through the basilic vein and advanced to the SVC.